Thank you MatthiasF.
I am new here and am discovering that there is a lot more than the manuals in these forums, so will explore more.

The post in Profilux 4 forum
Mail provider settings/setup for mail sending with ProfiLux 4
and particularly the answer by premiero (2fa is 2 step authentication):

https://forum.aquariumcomputer.com/s...ith-ProfiLux-4

There is a better, secure way to allow P4 to send email via gmail.

1. First of all, go to https://myaccount.google.com/security and activate 2fa on google account.
2. Next, go to https://myaccount.google.com/apppass...utm_medium=web and create APP Password. I attach printscreen with a step by step guide.

Click image for larger version. Name: P4 email 2.jpg Views: 23 Size: 85.7 KB ID: 11513

So first you have to open drop down menu and pick "other app". Next enter app name (I typed Profilux 4) and click "generate". Google will create 16 letter password - copy and paste it to profilux 4 password field. Than click done.

After this you can put your credentials in P4 like below:

Click image for larger version. Name: P4 email.png Views: 21 Size: 12.4 KB ID: 11514