These are very strange drivers because the "USB Serial Port" under COM & LPT only appears in Device Manager when the USB cable is connected to the PC and the ProfiLux. When the cable is disconnected the port disappears. So in order to unistall the driver, the two must be connected.
This is not strange, that is normal. Any hardware with USB connection akts like this.

In the "System"->"Communication" menu on the ProfiLux there are three items, COM1, COM2 and LAN. Are there any specific settings for these items?
Make sure that the device address under "System"->"Communication"->"COM" have the same number as the device address in Edit Connection in ProfiLuxControl.


You have a PM.